The Use of Very-Low-Dose Methadone for Palliative Pain Control and the Prevention of Opioid Hyperalgesia
Opioid dose escalation may cause hyperalgesia, mediated by the N-methyl-D-aspartate (NMDA) pathway. Methadone is an atypical opioid that inhibits hyperalgesia through NMDA blockade, especially at low doses. Objective: To evaluate the efficacy of using very-low-dose methadone as the sole long-acting opioid agent in a hospice practice.
Exploring The Potential Role Of Mesocorticolimbic Circuitry In Motivation For And Adherence To Chronic Pain Self-management Interventions
Adherence to pain self-management strategies plays a crucial role in improving psychobehavioral outcomes for individuals with chronic pain. However, achieving substantive adherence to these treatments, which teach adaptive skills, is often challenging, leading to negative consequences for both individuals and society. Motivation for behavior change is identified as a key predictor of treatment adherence, yet […]
Long-term Trajectories Of Chronic Musculoskeletal Pain
Lots of people (40-50%) experience chronic pain, especially in muscles and joints. This can make daily life tough and cost a lot for healthcare. Researchers are studying how this pain changes over time to find better ways to manage it.
The Fit-for-Purpose Model: Conceptualizing and Managing Chronic Non-specific Low Back Pain as an Information Problem
Chronic back pain is a major issue with limited treatment options. While combining therapies helps, more progress needs understanding the complex factors that contribute to the pain.
Physiotherapy For Chronic Pelvic Pain: A Review of The Latest Evidence
Positive Childhood Experiences and Adult Mental and Relational Health in a Statewide Sample
Associations between adverse childhood experiences (ACEs) and risks for adult depression, poor mental health, and insufficient social and emotional support have been documented. Less is known about how positive childhood experiences (PCEs) co-occur with and may modulate the effect of ACEs on adult mental and relational health. OBJECTIVE To evaluate associations between adult-reported PCEs and […]
Physical Activity and Pain In People With and Without Cancer
Exercise has been shown to be effective for chronic non-cancer pain, but evidence for its efficacy in cancer pain is less clear. A new study has shown that exercising for upwards of 30 minutes most days may help relieve pain in patients who’ve been diagnosed with cancer, evaluating the exercise and pain outcomes from 10,000 patients […]
The mechanisms and management of persistent postsurgical pain
An estimated 10%–50% of patients undergoing a surgical intervention will develop persistent postsurgical pain (PPP) lasting more than 3 months despite adequate acute pain management and the availability of minimally invasive procedures. The link between early and late pain outcomes for surgical procedures remains unclear —some patients improve while others develop persistent pain. The elective […]
Complex Regional Pain Syndrome – Autoimmune or Functional Neurologic Syndrome
One of the great challenges of medicine is to effectively manage pain, a symptom that accompanies many illnesses or injuries. Patients who voice physical symptoms like pain for which no disease cause can be found are extraordinarily common across all medical disciplines. Pain is a symptom that exists to alert us to an injury or […]
The Effectiveness of Rehabilitation Interventions on Pain and Disability for Complex Regional Pain Syndrome- A Systematic Review and Meta-analysis
Delving into the effectiveness of rehabilitation interventions for Complex Regional Pain Syndrome (CRPS). Our systematic review & meta-analysis of RCTs provides critical insights into pain & disability management.