Persistent physical symptoms, also known as persistent somatic symptoms, encompass distressing somatic complaints lasting several months or more, regardless of their cause. These symptoms, often resulting in significant disability, pose a major burden on patients, healthcare professionals, and society. They can arise from infections, injuries, medical conditions, stressful life events, or appear without a clear origin. Diagnosing and treating these symptoms is challenging due to their complex and multifactorial nature, involving biological and psychosocial risk factors. Effective care requires addressing underlying pathophysiology, employing person-centred communication techniques, and, if needed, utilizing targeted psychological and pharmacological interventions. Understanding the persistence of somatic symptoms is key to providing personalized treatment and reducing stigma for affected patients.