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IASP PAIN: Volume 156, Issue 12, December 2015

PAINPAIN®  Now Available Online: Volume 156, Issue 12, December 2015 IASP Members: To read PAIN online, login at and click on the journal cover on the bottom of the IASP home page. IASP members receive online access to as a benefit of membership. However, many members also enjoy access to PAIN through their institution. If you find that your institution does not have access to PAINon the Ovid platform, please consider requesting that your librarian add PAINto the institution’s collection so that faculty, students, and residents can also access content in PAIN. Institutions/librarians wishing to obtain an electronic subscription can email or contact the nearest Ovid Regional Sales Office. Visit and select Contact and Locations. Download the iPad App. You can read PAIN on the iPad and on Android tablets and smartphones. You will find the best in digital technology, with article-sharing features, multimedia links, and more.


In Memoriam Jean-Marie Besson 1938 to 2014
Bouhassira, Didier; Villanueva, Luis


Should we use gabapentin for postoperative pain control?
Fletcher, Dominique; Martinez, Valéria

Importance of knowing your stimulation paradigm: methodological considerations on laser-evoked pain responses in rats and humans
Hess, Andreas

PAIN Pictured

Diversity of composition and function of sodium channels in peripheral sensory neurons
Dib-Hajj, Sulayman D.; Waxman, Stephen G.

Topical Review

Men, masculinity, and pain Editor’s Choice
Keogh, Edmund

Research Paper

Predictive factors for the development of persistent pain after breast cancer surgery
Andersen, Kenneth Geving; Duriaud, Helle Molter; Jensen, Helle Elisabeth; Kroman, Niels; Kehlet, Henrik

Quality assurance for Quantitative Sensory Testing laboratories: development and validation of an automated evaluation tool for the analysis of declared healthy samples
Vollert, Jan; Mainka, Tina; Baron, Ralf; Enax-Krumova, Elena K.; Hüllemann, Philipp; Maier, Christoph; Pfau, Doreen Barbara; Tölle, Thomas; Treede, Rolf-Detlef

Chloride dysregulation and inhibitory receptor blockade yield equivalent disinhibition of spinal neurons yet are differentially reversed by carbonic anhydrase blockade
Lee, Kwan Yeop; Prescott, Steven A.

Analgesic and sedative effects of perioperative gabapentin in total knee arthroplasty: a randomized, double-blind, placebo-controlled dose-finding study
Lunn, Troels Haxholdt; Husted, Henrik; Laursen, Mogens Berg; Hansen, Lars Tambour; Kehlet, Henrik

Was it a pain or a sound? Across-species variability in sensory sensitivity Editor’s Choice
Hu, Li; Xia, Xiaolei L.; Peng, Weiwei W.; Su, Wenxin X.; Luo, Fei; Yuan, Hong; Chen, Antao T.; Liang, Meng; Iannetti, Giandomenico

A phase 3, multicenter, randomized, double-blind, placebo-controlled, safety, tolerability, and efficacy study of Xtampza ER in patients with moderate-to-severe chronic low back pain
Katz, Nathaniel; Kopecky, Ernest A.; O’Connor, Melinda; Brown, Robert H.; Fleming, Alison B.

Heightened cold pain and pressure pain sensitivity in young female adults with moderate-to-severe menstrual pain
Slater, Helen; Paananen, Markus; Smith, Anne J.; O’Sullivan, Peter; Briggs, Andrew M.; Hickey, Martha; Mountain, Jenny; Karppinen, Jaro; Beales, Darren

Roles of prefrontal cortex and paraventricular thalamus in affective and mechanical components of visceral nociception
Jurik, Angela; Auffenberg, Eva; Klein, Sabine; Deussing, Jan M.; Schmid, Roland M.; Wotjak, Carsten T.; Thoeringer, Christoph K.

Histamine H4 receptor activation alleviates neuropathic pain through differential regulation of ERK, JNK, and P38 MAPK phosphorylation
Sanna, Maria D.; Stark, Holger; Lucarini, Laura; Ghelardini, Carla; Masini, Emanuela; Galeotti, Nicoletta

Learned control over spinal nociception reduces supraspinal nociception as quantified by late somatosensory evoked potentials
Ruscheweyh, Ruth; Bäumler, Maximilian; Feller, Moritz; Krafft, Stefanie; Sommer, Jens; Straube, Andreas

Protein kinase C gamma-mediated phosphorylation of GluA1 in the postsynaptic density of spinal dorsal horn neurons accompanies neuropathic pain, and dephosphorylation by calcineurin is associated with prolonged analgesia
Miletic, Gordana; Hermes, Jessie L.; Bosscher, Georgia L.; Meier, Brenton M.; Miletic, Vjekoslav

The influence of offset analgesia on the onset and offset of pain in patients with fibromyalgia
Oudejans, Linda C.J.; Smit, Jeff M.; van Velzen, Monique; Dahan, Albert; Niesters, Marieke

Involvement of peripheral artemin signaling in tongue pain: possible mechanism in burning mouth syndrome
Shinoda, Masamichi; Takeda, Mamoru; Honda, Kuniya; Maruno, Mitsuru; Katagiri, Ayano; Satoh-Kuriwada, Shizuko; Shoji, Noriaki; Tsuchiya, Masahiro; Iwata, Koichi

Preoperative dexamethasone reduces acute but not sustained pain after lumbar disk surgery: a randomized, blinded, placebo-controlled trial
Nielsen, Rikke V.; Siegel, Hanna; Fomsgaard, Jonna S.; Andersen, Johnny D.H.; Martusevicius, Robertas; Mathiesen, Ole; Dahl, Jørgen B.

Somatosensory assessment and conditioned pain modulation in temporomandibular disorders pain patients
Kothari, Simple Futarmal; Baad-Hansen, Lene; Oono, Yuka; Svensson, Peter

Inhibition of the primary sensorimotor cortex by topical anesthesia of the forearm in patients with complex regional pain syndrome
Strauss, Sebastian; Grothe, Matthias; Usichenko, Taras; Neumann, Nicola; Byblow, Winston D.; Lotze, Martin

Conditioned place preference and spontaneous dorsal horn neuron activity in chronic constriction injury model in rats
Dalm, Brian D.; Reddy, Chandan G.; Howard, Matthew A.; Kang, Sinyoung; Brennan, Timothy J.

Wnt/Ryk signaling contributes to neuropathic pain by regulating sensory neuron excitability and spinal synaptic plasticity in rats
Liu, Su; Liu, Yue-Peng; Huang, Zhi-Jiang; Zhang, Yan-Kai; Song, Angela A.; Ma, Ping-Chuan; Song, Xue-Jun

Randomized, double-blind, comparative-effectiveness study comparing pulsed radiofrequency to steroid injections for occipital neuralgia or migraine with occipital nerve tenderness
Cohen, Steven P.; Peterlin, B. Lee; Fulton, Larry; Neely, Edward T.; Kurihara, Connie; Gupta, Anita; Mali, Jimmy; Fu, Diana C.; Jacobs, Michael B.; Plunkett, Anthony R.; Verdun, Aubrey J.; Stojanovic, Milan P.; Hanling, Steven; Constantinescu, Octav; White, Ronald L.; McLean, Brian C.; Pasquina, Paul F.; Zhao, Zirong

Role of brainstem serotonin in analgesia produced by low-intensity exercise on neuropathic pain after sciatic nerve injury in mice
Bobinski, Franciane; Ferreira, Tamara A.A.; Córdova, Marina M.; Dombrowski, Patrícia A.; da Cunha, Cláudio; Santo, Caroline C. do Espírito; Poli, Anicleto; Pires, Rita G.W.; Martins-Silva, Cristina; Sluka, Kathleen A.; Santos, Adair R.S.

Construct validity and reliability of a real-time multidimensional smartphone app to assess pain in children and adolescents with cancer
Stinson, Jennifer N.; Jibb, Lindsay A.; Nguyen, Cynthia; Nathan, Paul C.; Maloney, Anne Marie; Dupuis, L. Lee; Gerstle, J. Ted; Hopyan, Sevan; Alman, Benjamin A.; Strahlendorf, Caron; Portwine, Carol; Johnston, Donna L.

Increasing placebo responses over time in U.S. clinical trials of neuropathic pain
Tuttle, Alexander H.; Tohyama, Sarasa; Ramsay, Tim; Kimmelman, Jonathan; Schweinhardt, Petra; Bennett, Gary J.; Mogil, Jeffrey S.

Clinical Note

Contributions of physical function and satisfaction with social roles to emotional distress in chronic pain: a Collaborative Health Outcomes Information Registry (CHOIR) study
Sturgeon, John A.; Dixon, Eric A.; Darnall, Beth D.; Mackey, Sean C.


Importance of quantifying indirect effects from mediation analyses
Lee, Hopin; Hübscher, Markus; McAuley, James H.

Further verification by bootstrapped mediation analyses that pain catastrophizing modulates pain report but not spinal nociception: a reply to Lee, Hübscher, and McAuley
Rhudy, Jamie L.; Terry, Ellen L.



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