PainSA is a chapter of the International Association for the Study of Pain. Our mission is to improve all aspects of pain management in Southern Africa.

Evaluation of Buprenorphine Rotation in Patients Receiving Long-term Opioids for Chronic Pain- A Systematic Review

The potential harms of long-term opioids are well known. However, it is unclear whether rotation from a full opioid agonist to a partial opioid agonist, buprenorphine, is associated with improved pain-related outcomes and acceptable adverse effects in patients with chronic pain and long-term use of opioids. This systematic review of 22 studies that addressed prespecified outcomes of rotation to buprenorphine suggests with low-quality evidence that buprenorphine rotation was associated with reduced pain without precipitating opioid withdrawal or other serious adverse effects, and to aid mitigation of the harms of long-term opioid therapy.