PainSA is a chapter of the International Association for the Study of Pain. Our mission is to improve all aspects of pain management in Southern Africa.

A human TRPV1 genetic variant within the channel gating domain regulates pain sensitivity in rodents

Natural resistance to capsaicin’s effect in birds drove researchers to investigate a specific genetic variant that appears to be associated with pain resistance. They discovered the K710N human variant dialled down pain associated with capsaicin while enhancing the protective benefits of TRPV1. The findings could pave the way for the development of new treatments to manage pain.